科研及教学课题
1.广东省自然科学基金面上项目,2022A1515010092,黄芩汤重塑肠道氨基酸代谢激活mTOR通路修复结肠屏障功能治疗溃疡性结肠炎的机制研究,2022/01-2024/12,10万元,在研,项目负责人
2. 广东省自然科学基金面上项目,2019A1515010819,基于NLRP3炎症小体介导的分子平台研究氧化小檗碱调控溃疡性结肠炎的作用机制,2019/10-2022/09,10万元,在研,项目负责人
3. 广东省普通高校青年创新人才类项目,2018KQNCX045,基于系统药理学的六味顺激方治疗腹泻型肠易激综合征的作用机理研究,2019/05-2021/05,5万元,已结题,项目负责人
4. 广东省教育部产学研结合项目,2013B090600007,广藿香抗光老化系列化妆品的关键技术攻关与产业化研究,2013/12-2017/12,80万元,已结题,项目负责人
5. 广东省中医药局科研课题,20122153,一种养胃健脾中药保健饮料的开发研究,2012/10-2013/10,自筹,已结题,项目负责人
6.广州市基础与应用基础研究项目,202002030222,基于“肠道菌群-宿主”共代谢轴探讨黄芩汤治疗溃疡性结肠炎的作用机制,2020/04-2023/03,20万元,在研,第二参与人
7. 广东省自然科学基金面上项目,2019A1515010673,基于全微生物组关联分析的黄芩汤治疗溃疡性结肠炎的机制研究,2019/10-2022/09,10万元,在研,第三参与人
8. 广东省普通高校省级重大科研项目,2017KZDXM017,黄芩汤抑制ILC3s在溃疡性结肠炎过度CD4+T细胞免疫应答中的作用及机制研究,2018/06-2020/06,30万元,已结题,第三完成人
9. 广州中医药大学一流学科研究特色培育项目,XKP2019007,中药复方及成分、组分防治炎症性肠病的药效物质基础及作用机理研究,2019/01-2021/12,已结题,主要完成人
10. 广州中医药大学一流学科研究重大项目,XK2019002,基于鸦胆子有效部位的中医药防治癌症及炎症性肠病的应用研究,2019/01-2021/12,已结题,主要完成人
代表性研究论文
1. Xiaoqi Huang1, Zhiwei Chen1, Minyao Li, Yaomin Zhang Shijie Xu, Haiyang Huang, Xiaoli Wu* Xuebao Zheng*. Herbal pair Huangqin-Baishao: mechanismsunderlying inflammatory bowel disease bycombined system pharmacology and cellexperiment approach[J], BMC Complementary Medicine and Therapies, 2020(20): 292
2. Yuxuan Gan, Gaoxiang Ai, Jiazhen Wu, Huijuan Luo, Liping Chen, Qionghui Huang, Xue Wu, Nan Xu, Minyao Li, Ziren Su, Yuhong Liu*, Xiaoqi Huang*. Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport[J], Journal of Ethnopharmacology, 2020(250): 112519
3. Min-yao Li,Mu-xia Li, Nan Xu,Ze-hao Li,Yao-min Zhang,Yu-xuan Gan,Hui-juan Luo,Chang-lin Zhou,Yu-hong Liu,Zi-ren Su,Xiao-qi Huang* and Xue-bao Zheng*. Effects of Huangqin Decoction on Ulcerative Colitis by Targeting Estrogen Receptor Alpha and Ameliorating Endothelial Dysfunction Based on System Pharmacology[J], Journal of Ethnopharmacology, 2021(271): 113886
4. Min-yao Li, Hui-juan Luo, Xue Wu, Yu-hong Liu, Yu-xuan Gan, Nan Xu,Yao-min Zhang, Shu-hua Zhang, Chang-lin Zhou, Zi-ren Su, Xiao-qi Huang* and Xue-bao Zheng*. Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways[J], Frontiers in Pharmacology, 2020(10): 1552.
5. Jin Guan1, Xiao-Qi Huang1, Jia-Lei Dong, Hui-Min Lu, Yue-Wei Lin, Mei Liu, Zhi-Biao Yi, Li-Min Wu,Yong-Ming Huang, Tian Lan*. A novel mouse model of hyperuricemia and gouty nephropathy[J], Chinese Medical Journal 2020;133(16)
6. Wen-Hao Yang, Yu-Hong Liu, Jia-Li Liang, Zhi-Xiu Lin, Qiu-Lin Kong, Yan-Fang Xian, Da-Qing Guo, Zheng-Quan Lai, Zi-Ren Su* and Xiao-Qi Huang*. β-Patchoulene,isolated from patchouli oil,suppresses inflammatory mediators in LPS-stimulated RAW264.7 macrophages[J], European Journal of Inflammation, 2017,15(2): 136-141.
7. Chen XY, Chen HM, Liu YH, Zhang ZB, Zheng YF, Su ZQ, Zhang X, Xie JH, Liang YZ, Fu LD, Lai XP, Su ZR*, Xiao-Qi Huang*. The gastroprotective effect of pogostone from Pogostemonis Herbal against indomethacin-induced gastric ulcer in rats[J], Experimental Biology and Medicine, 2016, 241(2): 193-204.
8. Chen YL1, Huang XQ1, Xu SJ, Liao JB, Wang RJ, Lu XF, Xie YL, Zhou FS, Su ZR*, Lai XP*. Relieving visceral hyperalgesia effect of Kangtai capsule and its potential mechanisms via modulating the 5-HT and NO level in vivo[J], Phytomedicine, 2013,20(2): 249-257.
9. 黄晓其,吴晓丽,颜思珊,兰天. 蜂胶对Triton-WR1339所致高脂血症小鼠的降脂作用及调控脂质代谢机制, 南方医科大学学报, 2018, 38(8):1020-1024