翟筠秋
副研究员、博士生导师
Email: jqzhai@gzucm.edu.cn
广州中医药大学杏林青年学者，中药药剂学科青年学科带头人。研究方向为癌细胞的精准识别、生物标志物的高灵敏检测。
教育、工作经历:
2018/07-至今，广州中医药大学，中药学院，校聘研究员、副研究员
2013/09-2018/07，北京大学，化学与分子工程学院，博士；导师：赵美萍
2009/09-2013/07，四川大学，化学学院，学士
承担课程：
药学导论、药用高分子材料学
学术兼职:
中国分析测试协会青年委员会委员
广东省药学会生物医药专业委员会委员
广东省精准医学应用学会医工结合分会常务委员
广东省分析测试协会质谱专业委员会委员
《分析试验室》期刊青年编委
《分析测试学报》期刊青年编委
《Biomedical Analysis》期刊青年编委
荣誉奖励:
2023年 广州中医药大学优秀硕士学位论文指导教师
2023年 广州中医药大学实验室安全微视频创作大赛一等奖指导教师
2021年 广州中医药大学优秀女教职工
2017年 中国分析测试协会科学技术三等奖（2/4）
2017年 博士生国家奖学金
2013年 四川省优秀大学毕业生
2013年 四川大学优秀毕业生干部
2012年 本科生国家奖学金
2011年 本科生国家奖学金
科研项目
(1) 国家自然科学基金青年科学基金项目，22104022，2022/01-2024/12, 30万元，主持。
(2) 广东省自然科学基金青年提升（优秀青年）项目，2023A1515030206, 2023/01-2025/12, 30万元，主持。
(3) 广东省自然科学基金面上项目，2025A1515012805，2025/01-2027/12，10万元，主持。
(4) 广东省自然科学基金面上项目，2021A1515010169，2021/01-2023/12，10万元，主持。
(5) 广东省自然科学基金青年基金项目，2019A1515110783，2020/01-2022/8/24，10万元，主持, 结题。
(6) 广州市科技局青年博士启航项目，2024A04J5222，2024/01-2025/12。5万元，主持。
(7) 广东省教育厅青年创新人才项目，2018KQNCX039，2019/01-2020/12，5万元，主持，结题。
(8) 广东省教育厅创新人才项目，2024KTSCX112，2024/10-2026/10，2.5万元，主持。
(9) 广州中医药大学杏林青年学者人才经费，2018/07-2021/06，80万元，主持，结题。
发表SCI论文
(1) Junqiu Zhai, Muhua Zhao, Xiangjian Cao, Mengyuan Li, Meiping Zhao*. Metal-ion-responsive bio-nanocomposite for selective and reversible enzyme inhibition. Journal of the American Chemical Society, 2018, 140(49), 16925-16928. [大类1区, TOP, IF=14.5]
(2) Keni Ning#, Xiaoyan Tang#, Zhe Li, Liting Zhong, Yingchen Zhou, Jiaen Wang, Wanyi Huang, Han Zhang, Jiajun Ke, Tiangang Luan*, Shuobin Chen*, and Junqiu Zhai*. Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe. Advanced Science, 2024, 2413368. [大类1区, TOP, IF=14.3]
(3) Wenjuan Huang, Jiaqi Wang, Cheng Wang, Yuanfang Liu, Wentao Li, Qiaozhen Chen, Junqiu Zhai*, Zhenyang Xiang*, and Chaoxing Liu*. Expanding Cas12a Activity Control with an RNA G-quadruplex at the 5' End of CRISPR RNA. Advanced Science, 2024, 2411305. [大类1区, TOP, IF=14.3]
(4) Xinyu Luan, Xiaoyan Tang, Jiewei Deng, Yunyun Yang, Junqiu Zhai*, Tiangang Luan*. Fluorescent nucleic acid probes for DNA repair enzymes: Design strategies and applications. TrAC-Trends in Analytical Chemistry. 2024, 171, 117489. [大类1区, TOP, IF=11.8]
(5) Liuting Zhong#, Junqiu Zhai#, Yan Ma#, Yihong Huang, Yongrui Peng, Yu-e Wang, Zhuo Peng, Hailing Gan, Zhongwen Yuan, Pengke Yan, Qingguo Li, and Shixia Guan*. Molecularly Imprinted Polymers with Enzymatic Properties Reduce Cytokine Release Syndrome. ACS Nano. 2022, 16, 3, 3797–3807. [大类1区, TOP, IF=15.8]
(6) Xiaoyan Tang, Han Zhang, Jiajun Ke, Xinyu Luan, Ziqing Li, Tiangang Luan*, Junqiu Zhai*. A Localized DNA Logic Circuit Equipped with Cascade Amplifiers for Precise Identification of Cancer Cells. Analytical Chemistry, 2025, DOI：10.1021/acs.analchem.5c00247. [大类1区, TOP, IF=6.8]
(7) Junqiu Zhai#*, Han Zhang#, Wenzhi Zhu, Jiewei Deng, Xinyan Li, Tiangang Luan*. Real-Time Dynamic Tracking of Multiple Base Excision Repair Enzymes in Living Cells. Analytical Chemistry, 2025, 97, 4841-4849. [大类1区, TOP, IF=6.8]
(8) Junqiu Zhai*, Fanglin Huang, Xiaoxin Liu, Yunyun Yang, Tiangang Luan, Jiewei Deng*. Development of A Repair Enzyme Fluorescent Probe to Reveal the Intracellular DNA damages Induced by Benzo[a]pyrene in Living Cells. Analytical Chemistry, 2023, 95, 19, 7788-7795. [大类1区, TOP, IF=6.8]
(9) Cheng Tian#, Guangzhong Liang#, Chunyi Wang#, Ruikai He, Keni Ning, Zhe Li, Runduo Liu, Yan Ma, Shixia Guan, Jiewei Deng, Junqiu Zhai*. Computer Simulation and Design of DNA-Nanoprobe for Fluorescence Imaging DNA Repair Enzyme in Living Cells. Biosensors & Bioelectronics, 2022, 211, 114360. [大类1区, TOP, IF=10.7]
(10) Junqiu Zhai, Yibin Liu, Shan Huang, Simin Fang, Meiping Zhao*. A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells. Nucleic Acids Research, 2017, 45(6), e45. [大类2区, TOP, IF=16.7]
(11) Dong-Yang Zhang#, Fanglin Huang#, Yan Ma, Guangzhong Liang, Zhuo Peng, Shixia Guan*, Junqiu Zhai*. Tumor Microenvironment Responsive Theranostic Nanoplatform for Guided Molecular Dynamic/Photodynamic Synergistic Therapy. ACS Applied Materials & Interfaces, 2021, 13, 17392-17403. [大类2区, TOP, IF=8.5]
(12) Zhuo Peng#, Keni Ning#, Xiaoyan Tang, Ruikai He, Dong-Yang Zhang, Yan Ma, Shixia Guan*, Junqiu Zhai*. A multifunctional DNA repair enzyme and magnetic dual-triggered theranostic nanosystem for intelligent drug delivery. Materials & Design, 2023, 226, 111611. [大类2区, TOP, IF=7.6]
(13) Yiming He, Yihong Huang, Huahua Xu, Xufeng Yang, Nan Liu, Yongxin Xu, Renhuan Ma, Junqiu Zhai*，Yan Ma*，Shixia Guan*. Aptamer-modified M cell targeting liposomes for oral delivery of macromolecules. Colloids and Surfaces B: Biointerfaces, 2023, 222: 113109. [小类1区, TOP, IF=5.4]
(14) Yan Ma, Dong-yang Zhang, Zhuo Peng, Shixia Guan*, Junqiu Zhai*. Delivery of Platinum (IV) Prodrugs via Bi2Te3 Nanoparticles for Photothermal-Chemotherapy and Photothermal/Photoacoustic Imaging. Molecular Pharmaceutics, 2020, 17(9), 3403-3411.
(15) Junqiu Zhai, Qingguo Li, Huahua Xu, Tiantian Su, Yu-e Wang, Wenhai Huang, Yan, Ma*, Shixia Guan*. An aseptic one-shot bottom-up method to produce progesterone nanocrystals: controlled size and improved bioavailability. Molecular Pharmaceutics, 2019, 16(12), 5076-5084.
(16) Junqiu Zhai, Zhanlun Ou, Liuting Zhong, Yu-e Wang, Li-Ping Cao* and Shixia Guan*. Exenatide-loaded inside-porous poly(lacticco-glycolic acid) microspheres as a long-acting drug delivery system with improved release characteristics. Drug Delivery, 2020, 27(1), 1667-1675.
(17) Junqiu Zhai, Yu-e Wang, Xiangping Zhou, Yan Ma*, Shixia Guan*. Long-term sustained release poly(lactic-coglycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases. Drug Delivery, 2020, 27(1), 1283-1291.
(18) Yu-e Wang#, Junqiu Zhai#, Yuxiu Zheng, Jiali Pan, Xiaojia Liu, Yan Ma*, Shixia Guan*. Self-assembled iRGD-R7-LAHP-M nanoparticle induced sufficient singlet oxygen and enhanced tumor penetration immunological therapy. Nanoscale, 2022, 14(31): 11388-11406.
(19) Xufeng Yang, Yongrui Peng, Yu-a Wang, Yuxiu Zheng, Miming He, Jiali Pan, Nan Liu, Yongxin Xu, Renhuan Ma, Junqiu Zhai*，Yan Ma*，Shixia Guan*. Curcumae Rhizoma Exosomes-like nanoparticles loaded Astragalus components improve the absorption and enhance anti-tumor effect. Journal of Drug Delivery Science and Technology, 2023, 81, 104274.
(20) Zipeng Huang, Xinru Chen, Ying Li, Junqiu Zhai* and Yan Ma*. Excogitation and Assessment of Curcumin-Vitamin E Self-assembly PEGylated Nanoparticles by the Route of Oral Administration. Journal of Pharmaceutical Sciences, 2021, 110, 146-154.
(21) Ying Li, Pei Xiao, Zipeng Huang, Xinru Chen, Xia Yan, Junqiu Zhai* and Yan Ma*. Evaluation of curcumin-mediated photodynamic therapy on the reverse of multidrug resistance in tumor cells. RSC Advances, 2020, 10(1), 298-306.
授权专利：
1. 一种DNA链层在检测分子活性中的应用、DNA纳米荧光探针及其制备方法及应用。翟筠秋，梁光忠，黄方淋。ZL202110512946.6。
2. 脱碱基核酸内切酶磁性分子印迹纳米颗粒及其制备方法和应用。赵美萍，翟筠秋，李梦圆，曹翔剑。专利号：ZL201711348996.5。（授权公告号：CN108318693B； 授权公告日，2020.9.22）
3. 一种磁性复合纳米颗粒及其制备方法和应用。赵美萍，翟筠秋，刘艺斌，黄山，方思敏。ZL201610811557.2。
4. 一种实时定量荧光监测分子印迹过程的方法和应用。赵美萍，刘艺斌，翟筠秋。ZL201610165181.2。
5. 一种磁性分子印迹纳米颗粒及其制备方法和应用。赵美萍，刘艺斌，翟筠秋，董建桐。ZL201410539526.7。
