姓名：张容容

副教授、中药学硕士生导师

简介：主要从事中医药抗肿瘤药效物质基础、分子机制及“多成分-多靶点”互作规律研究。主持国家自然科学基金1项，广东省自然科学基金3项目，指导研究生获批科研项目4项，指导本科生获批创新实验室拔尖创新人才项目1项，指导研究生荣获国家奖学金1项，研究生优秀毕业论文2篇。近五年以第一/通讯作者在JACS, Advanced Science等国际知名高水平杂志发表SCI论文20余篇，其中IF大于10论文3篇，单篇最高影响因子16.6。申请发明专利19项，授权5项。主讲本科生专业课《中药化学》、《天然药物化学》，研究生专业课《有机化合物波谱解析》。参编《中药化学》教材，《中药分子靶点鉴定技术》专著。兼任中华中医药学会脑病分会委员，广东省药理学会中药药理专业委员会委员。

教育经历

[1]2012.9-2016.12，暨南大学-博士

[2]2015.10-2016.10，英国兰卡斯特大学-联合培养博士

[3]2010.9-2012.6，暨南大学-硕士

[4]2005.9-2009.6，山西中医药大学-学士

工作经历

[1]2024.7-至今，广州中医药大学-副教授

[2]2017.4-2024.7 至今，广州中医药大学-副研究员

研究方向：中药化学、中药抗肿瘤药理

研究领域：中药药效物质基础发现与药理作用机制研究

联系方式：zrr586@gzucm.edu.cn

研究课题

[1]第七批“双带头人”教师党支部书记工作室，中药学院国际中医药转化医学研究所党支部张容容工作室，2026-11至2029-11，1.5万元，在研，主持

[2]广东省科技厅，广东省自然科学基金-面上项目，2026A1515010594，肺癌源C5外泌体重塑脑部免疫微环境促进肺癌脑转移的分子机制及莪术倍半萜“多成分-多位点”的协同抑制用，2026-01至2028-12，10万元，在研，主持

[3]广州中医药大学青年拔尖人才培育“揭榜挂帅”项目，2026-01至2028-12，25万元，在研，主持

[4]广州中医药大学中西医结合提质扩容项目，2026-01至2027-12，30万元，在研，主持

[5]广东省科技厅，广东省自然科学基金-面上项目，2025A1515010571，莪术挥发油靶向S100A14外泌体抑制星型胶质细胞活化抗肺癌脑转移的药效物质及分子机制研究，2025-01至2027-12，10万元，在研，主持

[6]广东省科技厅，广东省自然科学基金-面上项目，2022A1515011212，岭南中药三叉苦抑制NLRP3炎性小体/caspase-1轴治疗阿尔兹海默症的药效物质基础及分子机制，2022-01至2024-12，10万元，结题，主持

[7]国家自然科学基金青年科学基金项目，81703814，断节参中C21甾苷类成分的分离鉴定及其肿瘤耐药逆转活性研究2018/01-2020/12，20万元，主持，结题。

代表性论文论著

[1]Zhang RR, Yu X, Du S, Hu R, Chen R, An L, Liu Z, Wang C. AVakognavine-Type Diterpenoid Alkaloid as FoxO1 Inhibitors against Rheumatoid Arthritis. J Am Chem Soc. 2026 Jul 8;148(26):27247-27259.

[2] Feng Q, Yang X, An L, Wang XY, Wang MR, Cai ZH, Xie CJ, Qiao LJ, Shen YB, Liang XM, Zhang R, Wang CY, Liu ZQ, Zhang RR. S100A14 in Tumor-Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect. Adv Sci (Weinh). 2026 Jul;13(39):e22921.

[3] Feng Q, Wang XY, Yang X, Liu GC, Xie CJ, Cai ZH, Wang MR, Zhang R, Liu ZQ, Zhang RR. Tumor-derived S100A14 targeted astrocytes via TLR4 to Recruit myeloid-derived suppressor cells promoting brain metastasis and Curdione reversal effect. Phytomedicine. 2026 Feb 11;153:157965.

[4]Ma Q, Qiu XY, Yang ZK, Zhang R, Wang Y, Feng Q, Liu ZQ, Zhang RR. Melomortsine A - D, unprecedented quinoline alkaloids with anti-breast cancer brain metastasis activity from Melodinus morsei Tsiang. Phytochemistry. 2027 Jan;253:115079.

[5]Du S, Cai Z, Wang M, Dai Y, Ji A, Feng Q, Liu Z, Zhang RR. Hypericum A-E: five unprecedented polycyclic polyprenylated acylphloroglucinols from Hypericum lagarocladum exhibiting PTP1B inhibitory activity. RSC Adv. 2026 Aug 17;16(41):48377-48387.

[6] Feng Q, Zhi JX, Wang XY, Chen YD, Liu GC, Wang CY, Yang

X, Feng FJ, Zhang R, Liu ZQ, Zhang RR. Cynanchum wallichii Wight and CW1 reversed docetaxel resistance effects by inhibiting P-gp and promoting PI3K/Akt-mediated apoptosis in prostate cancer. Biochem Pharmacol. 2025 Feb;232:116749.

[7] Feng Q, Li CZ, Zou YH, Wang XY, Yang X, Zhang R, Liu ZQ,Zhang RR. IL6/CCL2 from M2-polarized microglia promotes breast cancer brain metastasis and the reversal effect of β-elemene. Front Pharmacol. 2025 May 15;16:1547333.

[8]Hu RD, Lin WY, Feng Q, Liu J, Chen Y, Ji A, Wang C, Cao L,Zhang R, Liu Z, Cui H, Liang Q, Zhang RR. New α- Glucosidase Inhibitors from the Whole Plant of Hypericum beanii Based on Ligand Fishing and Molecular Networking Analysis. J Agric Food Chem. 2024 May 22;72(20):11452- 11464.

[9]Zhang J, Guo XJ, Chen XJ, Zhang RR, Ma BP, Liu ZQ. Entatisane diterpenoids from Euphorbia wallichii and their anti-influenza A virusactivity. Phytochemistry. 2024 Feb 3;220:113996.

[10] Ding XY, Wen JR, Lin WY, Huang GY, Feng Q, Duan L, Zhang SJ, Liu Z, Zhang RR, Wang Y. Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr. Phytochemistry. 2023 Sep;213:113774.

[11] Xiao X, Zhang X, Yang Z, Ji A, Wang C, Feng Q, Liu Z, Zhang RR. Six Unusual Meroterpenoids from the Leaves of Psidium guajava L. and Their PTP1B Inhibitory Activities. J Agric Food Chem. 2022 Apr 6;70(13):4000-4006.

[12] Ji AJ, Ma Q, Kong MY, Li LY, Chen XL, Liu ZQ, Wu JJ, Zhang RR. Two cardenolide glycosides from the seed fairs of Asclepias curassavica and their cytotoxic activities. Chin J Nat Med. 2022 Mar;20(3):202-209.

[13] Zhang L, Yuefang L, Min H, Wenbo C, Duan L, Liu Z, Lu L, Zhang RR. Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities. Phytochemistry. 2022 Jul;199:113172.