分子节律与代谢研究所
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王帅
发布时间:2021-07-02      来源:       点击:

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王帅

学位: 博士

职称: 研究员

E-mail:wangshuai@gzucm.edu.cn

个人荣誉: 广州中医药大学“杏林青年学者”

学术成绩:  已以第一或通讯作者在Science子刊(Sci Adv)、 Nature子刊(Nat Commun)、 Theranostics、 Biochem Pharmacol和Drug Metab Dispos等权威期刊发表SCI论文20篇。主持国自然面上项目/青年项目、省部级和博士后科学基金6项。

教育工作经历

2021/7-至今   广州中医药大学  中药学院  分子节律与代谢研究所   研究员

2019/7-2021/5 暨南大学 中西医结合博士后流动站 博士后

2014/9-2019/6 暨南大学 药学院    博士   导师:吴宝剑教授

2010/9-2014/6 齐鲁工业大学 化学与制药工程学院  学士

研究领域及方向

研究领域:药理学

研究方向

1)炎症/代谢性疾病和生物钟的交互作用机制

2)基于生物钟的药物代谢和转运研究

科研及教学课题

1. 国家自然科学基金面上项目,基于肝肠处置过程研究核受体NR1D1对溃疡性结肠炎治疗中糖皮质激素抵抗和稳态失衡的逆转作用, 82373940,在研,主持,49万元,2024.01-2027.12

2. 国家自然科学基金青年项目,生物钟调控溶质转运体和内外源物处置的作用机制研究, 82003839,在研,主持,16万元,2021.01-2022.12

3.中国博士后科学基金特别资助站前项目,LncRNA-Platr4协调生物钟对NLRP3炎症小体的节律性调控及分子机制研究,2019TQ0120,已结题,主持,18万元

4.中国博士后科学基金第66批面上资助项目,2019M663401,基于时钟因子REV-ERB的代谢性疾病调控和药靶研究,已结题,主持,8万元

5.广东省基础与应用基础研究基金联合基金青年项目,时钟因子E4BP4调控转运体SLCs及底物处置的机制研究,2019A1515110892,在研,主持,10万元,2020.1-2022.12

6.广东省自然科学基金面上项目,生物钟在肥胖-慢性炎症交互中的调控作用及分子机制研究,2021A1515012189,在研,主持,10万元,2021.1-2022.12

代表性研究论文

1.Shuai Wang, Yanke Lin, Feng Li, Zifei Qin, Ziyue Zhou, Lu Gao, Zemin Yang, Zhigang Wang, Baojian Wu*. An NF-κB driven lncRNA orchestrates colitis and circadian clock. Sci Adv. 2020, 6, eabb5202. (IF=14.136,一区)

2.Shuai Wang#, Yanke Lin#, Xue Yuan, Feng Li, Lianxia Guo, Baojian Wu*. REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis. Nat Commun. 2018, 9(1): 4246. (IF=14.919,一区)

3.Shuai Wang, Yanke Lin, Ziyue Zhou, Lu Gao, Zemin Yang, Feng Li, Baojian Wu*. Circadian clock gene Bmal1 regulates bilirubin detoxification: a potential mechanism of feedback control of hyperbilirubinemia. Theranostics. 2019,9(18):5122-5133. (IF=11.556,一区)

4.Shuai Wang, Feng Li, Yanke Lin, Baojian Wu*. Targeting REV-ERBα for therapeutic purposes: promises and challenges. Theranostics. 2020, 10(9):4168-4182. (IF=11.556,一区)

5.Shuai Wang, Xue Yuan, Danyi Lu, Lianxia Guo, Baojian Wu*. Farnesoid X receptor regulates SULT1E1 expression through inhibition of PGC1α binding to HNF4α. Biochem Pharmacol. 2017, 145: 202-209. (IF=5.858,二区)

6.Shuai Wang#, Feng Li#, Enxi Quan, Dong Dong*, Baojian Wu*. Efflux Transport Characterization of Resveratrol Glucuronides in UDP-Glucuronosyltransferase 1A1 Transfected HeLa Cells: Application of a Cellular Pharmacokinetic Model to Decipher the Contribution of Multidrug Resistance–Associated Protein 4. Drug Metab Dispos. 2016, 44(4): 485-488. (IF=3.922,三区)

7.Shuai Wang#, Huijie Xing#, Mengjing Zhao, Danyi Lu, Zhijie Li, Dong Dong, Baojian Wu*. Recent advances in understanding of kinetic interplay between Phase II metabolism and efflux transport. Curr Drug Metab. 2016, 17(10):922-929. (IF=3.731,三区)

8.Yanke Lin#, Shuai Wang#, Lu Gao, Ziyue Zhou, Zemin Yang, Jingpan Lin, Shujing Ren, HuijieXing*, Baojian Wu*. Oscillating lncRNA Platr4 regulates NLRP3 inflammasome to ameliorate nonalcoholic steatohepatitis in mice. Theranostics. 2021, 11(1): 426-444.(IF=11.556,共一,一区)

9.Yanke Lin#, Shuai Wang#, Ziyue Zhou, Lianxia Guo, Fangjun Yu, Baojian Wu*. The Clock Gene Bmal1 (Arntl) Controls Circadian Cytochrome P450 3a11 and Drug Detoxification. Commun Bio. 2019, 2:378.(IF=6.268,二区)

10.Mengjing Zhao#, Shuai Wang#, Feng Li, Dong Dong, Baojian Wu*. Arylsulfatase B mediates the sulfonation-transport interplay in human embryonic kidney 293 cells overexpressing sulfotransferase 1A3. Drug Metab Dispos. 2016, 44(9): 1441-1449.(IF=3.922,三区)

11.Feng Li#, Shuai Wang#, Danyi Lu, Yifei Wang, Dong Dong, Baojian Wu*. Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound. Xenobiotica. 2017, 47(5): 369-375.(IF=1.908,四区)

12.Ziyue Zhou#, Yanke Lin#, Lu Gao, Zemin Yang, Shuai Wang*, Baojian Wu*. Circadian pharmacological effects of berberine on chronic colitis in mice: role of the clock component Rev-erbα. Biochem Pharmacol. 2019, 113773.(IF=5.858,二区)

13.Yanke Lin#, Luomin Lin#, Lu Gao, Shuai Wang*, Baojian Wu*. Rev-erbα regulates hepatic ischemia-reperfusion injury in mice. Biochem Biophys Res Commun. 2020, 529: 916-921. (IF=3.575,三区)



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