中药资源科学与工程研究中心
刘永强
发布时间:2021-02-22      来源:       点击:

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刘永强

学位: 博士

职称: 副研究员

教育工作经历

2020/8-至今,副研究员,广州中医药大学 中药学院 中药资源科学与工程研究中心

2017/7-2020/7,副研究员,广州中医药大学 科技创新中心

2014/11-2017/6,博士后,美国福克斯蔡司癌症研究中心

2009/10-2013/12,博士,中国科学院 动物研究所膜生物学国家重点实验室

2007/7-2009/9, 硕士,中国科学院 广州生物医药与健康研究院

研究方向

1)中药抗肿瘤分子机制研究

2)肿瘤分子靶向治疗。

科研及教学课题

1. 广东省自然科学基金面上项目,2022A1515011881,化橘红有效成分通过靶向Skp2-SCF E3连接酶治疗非小细胞肺癌的作用机制研究,2022/01 至 2024/12,10万元, 在研, 主持。

2. 广东省区域联合基金地区培育项目,2021B1515140052, 基于Fanconi anemia通路介导化疗耐药研究鹅不食草及其有效成分联合顺铂治疗肺癌的作用机制,2021/10 至 2024/09,30万元, 在研, 主持。

3. 广东省医学科研基金面上项目,B2020014,F-box蛋白NIPA促进肺癌细胞增殖以及介导化疗耐药的分子机理研究,2020/07-2022/06,1.5万元,在研,主持。

4. 国家自然科学基金青年项目,小胶质细胞通过分泌IL-1β招募星形胶质细胞进而促进髓母细胞瘤发生的分子机理研究,81802776,2019/01-2021/12,21万元,已结题,主持。

5. 高水平大学建设杏林人才科研配套经费,2017.7-2020.7,40万元,主持。

承担课程

主要承担《生物学》等课程。

代表性研究论文

1.Guo-Sheng Lin, Rou-Qiao Zheng, …, Youliang Xie*, Huicai Huang*, Yong-Qiang Liu*. Proteomic screening identifies brusatol targets TGFβRII to suppresses non-small cell lung cancer metastasis. Phytomedicine, 2025, 139: 156468.

2.Hailong Liu, Jing Zhang, …, Yong-qiang Liu*, Xiaoguang Qiu*, Tao Jiang*. High cellular plasticity state of medulloblastoma local recurrence and distant dissemination. Cell Reports Medicine, 2025, 6, 101914.

3.Han-Chen Wang, Pei-En Wu, …, Yong-Xian Cheng*, Yong-Qiang Liu*. Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway.                                               Journal of Ethnopharmacology, 2025; 340: 119277.

4.Yu-Fei Chen, Yan-Chun Pang, …, Xiang-Zhen Fan*, Yong-Xian Cheng*, Yong-Qiang Liu*. Identification of arnicolide C as a novel chemosensitizer to suppress mTOR/E2F1/FANCD2 axis in non-small cell lung cancer. British Journal of Pharmacology, 2024; 181:1221–1237.

5.Da Huang, Pei-En Wu, …, Hui Xu*, Yong-Qiang Liu*. Ethanol Extract of Citrus grandis ‘Tomentosa’ Exerts Anticancer Effects by Targeting Skp2/p27 Pathway in Non-Small Cell Lung Cancer. Molecular Nutrition & Food Research, 2023; 67(18): 2300061.

6.Shangping Xing, …, Hui Xu, Yong-Qiang Liu*. Brusatol has therapeutic efficacy in non-small cell lung cancer by targeting Skp1 to inhibit cancer growth and metastasis. Pharmacological Research, 2022, 176: 106059.

7.Xiang-Zhen Fan, Yu-Fei Chen, Shi-Bing Zhang, Dan-Hua He, Su-Fen Wei, Qi Wang, Hua-Feng Pan*, Yong-Qiang Liu*. Centipeda minima extract sensitizes lung cancer cells to DNA-crosslinking agents via targeting Fanconi anemia pathway. Phytomedicine, 2021, 91: 153689.

8.Hailong Liu, Youliang Sun, …, Yong-qiang Liu*, Xinguang Yu* and Shiyu Feng*. Pro-inflammatory and proliferative microglia drive progression of glioblastoma. Cell Reports, 2021, 36(11): 109718.

9.Su-Fen Wei, …, Qi Wang*, Yong-Qiang Liu*. Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma. Biochemical Pharmacology, 2021, 190: 114593.

10.Yong-Qiang Liu*, Xiao-Lu Wang, Dan-Hua He, Yong-Xian Cheng*. Protection against chemotherapy- and radiotherapy-induced side effects: mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine, 2021, 80: 153402.

11.Yi-le Zhou, Yong-ming Yan, …, Hua-feng Pan*, Yong-xian Cheng*, Yong-Qiang Liu*. 6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Acta Pharmacologica Sinica, 2020, 41: 10–21.

12.Si-Yi Li, Yi-Le Zhou, …, Hua-Feng Pan*, Yong-Xian Cheng*, Yong-Qiang Liu*. Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-κB signaling pathway. Phytomedicine, 2020, 67: 153164.


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