何卓儒
中药炮制学讲师，中药学博士，现就职于广州中医药大学炮制与药事管理教研室。主要围绕有毒中药及其炮制品，聚焦特色毒效作用机制开展研究工作。
教育工作经历
2024.10-至今：广州中医药大学，炮制与药事管理教研室，讲师
2022.06-2024.07：广州中医药大学，中西医结合流动站，博士后
2019.09-2022.06：广州中医药大学，中药学专业，医学博士
2015.09-2018.06：广东药科大学，药剂学专业，医学硕士
2011.09-2015.06：广东药学院，药学专业，理学学士
研究领域及方向
有毒中药的炮制作用机理
科研及教学课题
1. 基于牛磺酸靶向代谢组学研究制附子作用于“肝-肠-关节”轴抗类风湿性关节炎的分子机制，国家自然科学基金青年科学基金项目，30万元，2024.01-2026.12，主持；
2. 含硫氨基酸代谢驱动胆汁酸-Th17/Treg通路在类风湿性关节炎中的分子机制及制附子的调控作用研究，中国博士后科学基金面上资助，8万元，2023.07-2025.07，主持；
3. 从“Nrf2/NOX2-ROS-干细胞”轴探讨PI3K介导的肺癌EGFR-TKI耐药热毒病机内涵及黄芩汤逆转耐药的功效机制，国家自然科学基金面上项目，49万元，2024.01-2027.12，参与（排名3/8）。
承担课程
承担《中药炮制学》教学任务
代表性论文
1. Zhang Caiping#, Zhang Yimin#, Liu Binjie, Chen Yongxv, Xie Yue, Huang Huiting*, Liu Zhongqiu*, He Zhuoru*. Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency. Journal of Proteome Research. 2024, 23(10): 4538-4552.
2. He Zhuoru, Luo Qing, Liu Zhongqiu, Gong Lingzhi. Extensive evaluation of sample preparation workflow for gas chromatography-mass spectrometry-based plasma metabolomics and its application in rheumatoid arthritis. Analytica Chimica Acta. 2020, 1131: 136-145.
3. He Zhuoru, Liu Zhongqiu, Gong Lingzhi. Biomarker identification and pathway analysis of rheumatoid arthritis based on metabolomics in combination with ingenuity pathway analysis. Proteomics. 2021, 21(11-12): e2100037.
4. He Zhuoru, Liu Zhongqiu, Gong Lingzhi. Systematic evaluation of sample preparation strategy for GC-MS-based plasma metabolomics and its application in osteoarthritis. Analytical Biochemistry. 2021, 621: 114153.
5. Li Kunping#, He Zhuoru#, Wang Xinqiuyue, Pinedac Miguel, Chen Runbao, Liu Haiqi, Ma Kaiting, Shen Huanjia, Wu Chunhui, Huang Ningtin, Pan Tianling, Liu Yun, Guo Jiao. Apigenin C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway. Free Radical Biology and Medicine. 2018, 124: 163-175.
6. Zheng Yuan#, He Zhuoru#, Kong Yu, Huang Xinjie, Zhu wei, Liu Zhongqiu, Gong Lingzhi. Combined Metabolomics with Transcriptomics Reveals Important Serum Biomarkers Correlated with Lung Cancer Proliferation through a Calcium Signaling Pathway. Journal of Proteome Research. 2021, 20(7): 3444-3454.
7. Huang Zhisheng#, He Zhuoru#, Kong Yu, Liu Zhongqiu, Gong Lingzhi. Insight into osteoarthritis through integrative analysis of metabolomics and transcriptomics. Clinica Chimica Acta. 2020, 510: 323-329.
8. Zhang Qisong#, He Zhuoru#, Liu Zhongqiu, Gong Lingzhi. Integrated plasma and liver gas chromatography mass spectrometry and liquid chromatography mass spectrometry metabolomics to reveal physiological functions of sodium taurocholate cotransporting polypeptide (NTCP) with an Ntcp knockout mouse model. Journal of Chromatography B. 2021, 1165: 122531.
9. 何卓儒, 张初梅, 梁秋萍, 等. 三白草中蜥尾草亭A和B的分离鉴定及其含量测定[J]. 药物分析杂志. 2018, 38(05): 776-781.
10. 何卓儒, 刘昌乐, 李坤平. 心磷脂重构与心血管疾病[J]. 中国生物化学与分子生物学报. 2016, 32(10): 1097-1104.
