安琳
职称:副教授 学位:博士
学院:中药学院
E-mail: anlin@gzucm.edu.cn
办公电话:020-39358560
办公室:广州大学城广州中医药大学药科楼B407-1
个人情况:硕士研究生导师、中药鉴定学青年学科带头人、中药学学科秘书
教育、工作经历:
2019年毕业于中国药科大学,获得生药学博士学位。同年进入广州中医药大学开展师资博士后工作,2021年考核优秀后留校任职,现为广州中医药大学中药学院中药鉴定学教研室骨干教师,兼任广东省药理学会中药药理专业委员会委员、广东省药理学会内分泌代谢病药理专业委员会委员。主要从事代谢性肝病的中药干预研究。主持国家级及省部级课题7项,参加国家级课题10余项,以第一或通讯作者身份在Pharmacological Research、Phytomedicine、Antioxidants & Redox Signaling等国际期刊发表SCI论文近20篇。《中药鉴定学》《生药学》等课程的主讲教师,荣获2020年度广州中医药大学教师讲课比赛一等奖,参与实践性教学改革项目2项。
研究方向:
研究领域:中药代谢药理
研究方向:(1)“肝-脑”轴代谢失衡及中药干预研究;
(2)中药效应物质鉴定及质量评价。
科研课题:
(1)国家自然科学基金青年项目,82104687,山茱萸环烯醚萜苷类成分通过上调溶酶体酸性脂肪酶抑制肝星状细胞活化的药效及作用机制,2022-01至2024-12,30万元,资助期满,主持。
(2)国家科技部,国家重点研发计划“中医药现代化”,2023YFC3502800,清热逐瘀类经典名方治疗结直肠癌的损补权衡功效机制及配伍规律,2024-01至2026-12,1800万元,在研,参与。
(3)广东省自然科学基金面上项目,2024A1515012631,从肝脑相维探讨山茱萸调控胆汁酸代谢改善肝脏损伤合并抑郁的作用研究,2024-01至2026-12,15万元,在研,主持。
(4)广东省自然科学基金委员会-区域联合青年项目,2019A1515110202,丹参素调节谷氨酰胺分解代谢抑制肝星状细胞活化的研究,2020-01至2022-12,10万元,结题,主持。
(5)中国博士后科学基金,特别资助(站中),2021T140145,基于溶酶体酸性脂肪酶探讨山茱萸环烯醚萜苷类成分抑制肝星状细胞活化的药效及作用机制研究,2021-01至2021-12,18万元,结题,主持。
(6)中国博士后科学基金面上项目,2020M672604,山茱萸环烯醚萜苷类成分调控溶酶体酸性脂肪酶抗肝纤维化损伤的药效及作用机制,2020-06至2021-12,8万元,结题,主持。
(7)广东省医学科学技术研究基金面上项目,20241119195211321,肝病合并抑郁症下“肝-肠-脑”轴胆汁酸代谢紊乱的分子机制研究,2025-07至2027-06,1万元,在研,主持。
(8)广州市科技局,青年博士“启航”项目,2025A04J4204,基于“肝-脑”轴胆汁酸代谢调控探讨肝病合并抑郁的分子机制及贯叶金丝桃的干预作用,2025-04至2027-03,5万元,在研,主持。
承担课程:
本科生教学:《中药鉴定学》《生药学》;
研究生教学:《分子生药学》。
代表论文:
[1] Liang Zuhui#, Ye Yingyi#, Deng Zhihong#, Lan Huan, Liu Caihong, Xu Yuanhang, Fan Minqi, Liu Zhongqiu, Wu Peng*, An Lin*, Wang Caiyan*. CHPF2 as a novel biomarker and ponicidin as a potential therapeutic agent in hepatocellular carcinoma. Pharmacological Research, 2025, Accepted.
[2] Liu Binjie, Shao Ting, Xiao Dandan, Yang Shujie, Lin Weijie, Sun Lizhu, Zhang Weiqin, Luo Meiqing, Zhao Jinlan, Yang Lei, Bai Shasha, Deng Di, Wang Caiyan, Wang Shaogui, Zhang Rong *, Liu Zhongqiu*, An Lin*. Aqueous extract of Cornus officinalis alleviates NAFLD via protecting hepatocytes proliferation through regulation of the tricarboxylic acid cycle, Journal of Ethnopharmacology, 2025, 342(119422).
[3] Wang Shanshan, Li, Qianbin, Deng Di, Xie Zedan, Cao Kerun, Zhang Fan, Yu Qingying, Li Zizheng, Ma Yuantian, Bai Shasha, Zhao Jinlan, Yang Lei, Liang Qi*, An Lin*, Zhang Rong*. Facilitating microglia M2 polarization alleviates p-Synephrine-induced depressive-like behaviours in CSDS mice via the 5-HT6R-FYN-ERK1/ 2 pathway, International Immunopharmacology, 2025, 147(113926): 1.
[4] Zhang Shanshan, Liu Binjie, Huang Lan, Zhang Rong, An Lin*, Liu Zhongqiu*. Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway. Journal of Molecular Medicine-JMM. 2024, 102(1):113-128.
[5] Liu Binjie, Zhang Shanshan, Sun Lizhu, Huang Lan, Zhang Rong, Liu Zhongqiu*, An Lin*. Unravelling the Link between Psychological Distress and Liver Disease: Insights from an Anxiety-like Rat Model and Metabolomics Analysis. International Journal of Molecular Sciences. 2023, 24(17):13356.
[6] An Lin, Zhang Mi, Lin Yuefang, Jiang Ting, Xu Keyang, Xiao Shilin, Cai Liming, Kwan Hiu Yee*, Liu Zhongqiu*, Su Tao*. Morroniside, a novel GATA3 binding molecule, inhibits hepatic stellate cells activation by enhancing lysosomal acid lipase expression. Phytomedicine. 2022, 103: 154199.
[7] Wu Binmin, Huang Lan, Wang Yange, Zeng Lishan, Lin Ying, Li Jingyan, Wang Shaogui*, Zhang Guifang*, An Lin*. Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling. Frontiers in Pharmacology. 2022, 13: 1043022.
[8] An Lin, Lin Yuefang, Li Leyan, Kong Muyan, Lou Yanmei, Wu Jinjun*, Liu Zhongqiu*. Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis. Frontiers in Pharmacology. 2021, 11: 0-618262.
[9] An Lin, Peng Li-Ying, Sun Ning-Yuan, Yang Yi-Lin, Zhang Xiao-Wei, Li Bin, Liu Baolin, Li Ping*, Chen Jun*. Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis. Antioxid Redox Signal. 2019, 30(15): 1831-1848.
[10] Peng Liying, An Lin (co-first); Sun Ningyuan; Ma Yi; Zhang Xiaowei; Liu Wenhua; Liu Baolin; Li Ping, Chen Jun*. Salvia miltiorrhiza Restrains Reactive Oxygen Species-Associated Pulmonary Fibrosis via Targeting Nrf2-Nox4 Redox Balance. Am J Chin Med. 2019, 47(5): 1113-1131.
[11] An Lin, Zhou Mei, Marikar Faiz M M T, Hu Xue-Wen, Miao Qiu-Yun, Li Ping, Chen Jun*. Salvia miltiorrhiza Lipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy through Activation of Nuclear Factor Erythroid 2-Related Factor 2. Am J Chin Med. 2017, 45(7): 1441-1457.
[12] Li Wengkun, Wu Binmin, Wang Yange, Lin Ying, An Lin*, Zhang Guifang*. The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus. Biomed Research International. 2021, 2021:9490162.
[13] Wang Tiantian, Zhang Lichun, Qin Zhen, Chen Shujun, Zeng Jingmin, Li Jingyan, An Lin, Wang Caiyan, Gao Yong, Wang Liming, Zhao Zhongxiang, Liu Zhongqiu*, Wang Shaogui*. Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation. Acta Pharmacologica Sinica. 2023, 44(12):2445-2454.
[14] Zhang, Xiaowei; Zhang, Ping; An, Lin; Sun, Ningyuan; Peng, Liying; Tang, Weiwei; Ma, Dingyuan; Chen, Jun. Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis. Acta Pharm Sin B. 2020, 10(8): 1397-1413.