药理方药学部
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王羚郦
发布时间:2025-12-02      来源:       点击:

姓名:王羚郦

职称:副研究员

教育经历

[1] 2008/9–2011/7,广州中医药大学,中药学,博士,导师:赖小平

[2] 2003/9–2006/7,中国药科大学,药物分析,硕士,导师:胡育筑

[3] 1999/9–2003/7,中国药科大学,药学,学士

工作经历

[1] 2019/6-至今,广州中医药大学,中药学院,副研究员

[2] 2019/2-2021-2,瑞典卡罗林斯卡医学院,访问学者

[3] 2012/6-2019/6,广州中医药大学,中医药数理工程研究院,副研究员

[4] 2006/7-2012/6,广州中医药大学,中药学院,讲师

研究方向:1.中药心血管药理2.中药抗肿瘤药理

联系方式:wlingli@gzucm.edu.cn

研究课题

[1]国家自然科学基金委员会,面上项目,82374054,基于“淡味渗泄”探讨当归芍药散调控脑-肠轴防治AD的药性基础,2024.01-2027.12,48万元

[2]东莞市科技局,社会科技发展重点项目,20211800905502,白术有效成分羽扇豆醇抗三阴性乳腺癌作用机制研究,2022-01至2023-12,10万元,

[3]广州市科技计划项目,202103000049,经典名优中成药活心丸毒性质量控制及标准化研究,2021.4-2024.3,300万元

[4]广东省中医药局项目,粤中医办函[2017]19号,名优中成药咳特灵的二次开发,2016.10-2019.10,300万元

[5]国家科技部国家重点研发计划项目,SQ2017YFC170406 / 01,面向“一带一路”国家的中医药国际合作示范研究 / 中药海外注册标准化路径制定2018.1-2020.1,885万元

[6]港澳台科技合作专项项目,粤港澳岭南中药综合开发研究,2014.04-2017.04,200万元

[7]东莞市国际科技合作(含港澳台)项目,2013508102021,食用燕窝国际标准研讨会,2014.12-2016.03,10万元

[8]国家自然科学基金面上项目,81173498,特异性DNA探针和特征肽指纹图谱技术在 燕窝质量评价中的应用,2011.9-2014.9,58万元

[9]国家科学技术部项目,2011CB505405,中医原创思维与健康状态辨识方法体系研究,2011.07-2014.07,8.8万元

[10]广东省自然科学基金项目,10152380800000000,苦参类生物碱逆转ABC蛋白族介导的肿瘤多药耐药研究,2010.10-2013.10,5万元

[11]广东省自然科学技术项目,2010B030700038,岭南药巴戟天抗衰老作用的开发与利用,2010.07-2013.07,4万元

[12]广东省自然科学技术项目,1011210200030,中药抗肿瘤新药化慈丹临床前研究,2010.03-2013.03,30万元

代表性论文论著

[1] Liao D, Yi R, Luo J, et al. Multi-level bioinformatics combined with in vitro and in vivo experiments reveal the nephrotoxicity risk of isotoosendanin. Ecotoxicol Environ Saf. Published online October 28, 2025. doi:10.1016/j.ecoenv.2025.119288

[2] Huang M, Wang L, Xu Z, et al. Huoxin Pill Ameliorates Atrial Fibrillation by Modulating Autonomic Nervous Balance and Electrical Conduction Heterogeneity: Insights From Systems Pharmacology and Experimental Validation. Basic Clin Pharmacol Toxicol. 2025;137(2):e70079. doi:10.1111/bcpt.70079

[3] Zhang M, Yuan W, Li C, et al. Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice. Front Pharmacol. 2025;16:1574039. Published 2025 Apr 28. doi:10.3389/fphar.2025.1574039

[4] Metabolomics and integrated network pharmacology analysis reveal attenuates cardiac hypertrophic mechanisms of HuoXin pill. J Ethnopharmacol. 2022;292:115150. doi:10.1016/j.jep.2022.115150

[5] Lupeol inhibits the proliferation and migration of MDA-MB-231 breast cancer cells via a novel crosstalk mechanism between autophagy and the EMT. Food Funct. 2022;13(9):4967-4976. Published 2022 May 10. doi:10.1039/d2fo00483f

[6] Rapid detection of PAH gene mutations in Chinese people. BMC Med Genet 20, 135 (2019) doi:10.1186/s12881-019-0860-5

[7] Longistyline A, a natural stilbene isolated from leaves of Cajanus cajan, exhibits significant anti-MRSA activity.Int J Antimicrob Agents 2019;:.DOI:10.1016/j.ijantimicag.2019.10.002

[8] PVT1 affects EMT and cell proliferation and migration via regulating p21 in triple-negative breast cancer cells cultured with mature adipogenic medium.[J]. Acta biochimica et biophysica Sinica,2018.

[9] Analysis of 2-(2-Phenylethyl)chromones by UPLC-ESI-QTOF-MS and Multivariate Statistical Methods in Wild and Cultivated Agarwood.[J]. International journal of molecular sciences,2016,17(5)

[10] Two acylated flavonoid glycosides from the leaves of Quercus dentata.[J]. Natural Product Communications, 2010, 5(10):1597-1599.

[11] Baicalin Promotes Mammary Gland Development via Its Steroid-like Activities

[12] Design and Synthesis of α-naphthoflavone Chimera Derivatives Able to Eliminate Cytochrome P450 (CYP)1B1-mediated Drug Resistance via Targeted CYP1B1 Degradation

[13] Discovery and optimization of selective RET inhibitors via scaffold hopping



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