罗霞

学位： 博士

职称： 教授

社会兼职：中华中医药学会免疫学分会副秘书长，中国免疫学会中医药免疫分会委员、广东省免疫学会委员

教育工作经历

2009/07-至今 广州中医药大学 中药学院 教授

2014/09-2017/06 广州中医药大学 中西医结合基础 博士  

2006/09-2009/06 广州中医药大学 中西医结合基础 硕士  

2001/09-2006/06 甘肃中医药大学 针灸推拿学 学士

研究方向

1） 中药抗炎免疫药理；2）黏膜免疫

主持科研项目

1. 国家自然科学基金，82474142，PAD4介导的蛋白瓜氨酸化修饰在溃疡性结肠炎中的机制及葛根芩连汤的干预作用，2025.01-2028.12，在研，49万元，主持

2. 广东省卫健委青年拔尖人才项目，0720240222，以溃疡性结肠炎瓜氨酸化自身抗原为基础的诊疗新靶点研究，2024.10-2027.09，在研，50万元，主持

3. 国家自然科学基金，81703785，黄芩汤修复微生物屏障及抑制MDP-NOD2炎症信号通路治疗炎症性肠病，2018.01-2020.12，结题，20万元，主持

4. 广东省自然科学基金面上项目，2024A1515012182，基于NETs对肿瘤生长的促进作用探讨黄芩汤防治CAC的机制，2024.01-2026.12，在研，15万元，主持

5. 广东省自然科学基金面上项目，2023A1515011141，基于PAD4介导的中性粒细胞陷阱探究甘草酸防治UC相关肿瘤的研究，2023.01-2025.12，在研，10万元，主持

6. 广东省教育厅高校科研项目生物医药与健康重点领域专项，2023ZDZX2020，甘草苷抑制巨噬细胞NOX2活性促进其降解肿瘤细胞的机制研究，2024.01-2025.12，在研，6万元，主持

7. 广州中医药大学青年英才项目，QNYC20190104，靶向芳香烃受体激活IL-22/STAT3信号通路在清热止痢复方修复肠上皮治疗肠炎中的作用，2019.11-2023.11，已结题，20万元，主持

8. 广州市科技计划项目，202201011631，黄芩汤通过YAP-MDSC免疫抑制微环境缓解结肠炎癌转化，2022.04-2024.03，已结题，5万元，主持

9. 广东省普通高校特色创新项目，2020KTSCX026, 黄芩素通过激活ILC3-AhR/IL-22通路修复肠上皮治疗溃疡性结肠炎，2020.06-2022.06，已结题，10万元，主持

10. 广东省普通高校特色创新项目，2017KTSCX042, 大黄素激活PPARγ信号产生三重效应发挥治疗IBD的作用，2018.01-2019.12，已结题，10万元，主持

11. 广东省自然科学基金面上项目，2015A030313344，从肠道菌群调控Th17/Treg探讨大黄牡丹汤治疗IBD的机制，2015.08-2018.08，10万元，已结题，主持

12. 广东省教育厅科研项目，2013LYM0014，肠道菌群作为四君子汤多糖改善脾虚小鼠免疫状态的作用靶点研究，2014.01-2015.12，3万元，已结题，主持

13. 广州中医药大学优秀青年学者科研基金，四君子汤多糖对抗生素引起小鼠菌群失调及免疫损伤的保护机制研究，2013.03-2015.12，5万元，已结题，主持

14. 广东省自然科学基金自由申请，2021A1515012219, 基于TL1A/DR3轴探讨大黄牡丹汤调控3型固有淋巴细胞治疗IBD的机制，2021.01-2023.12, 10万元，已结题，排名第二

15. 国家自然科学基金，81673668，大黄牡丹汤通过短链脂肪酸抑制“鞭毛蛋白-TLR5炎症信号通路”治疗IBD的机制研究，2017.01-2020.12，60万元，已结题，参加

16. 国家自然科学基，81603587，基于AnnexinA5-Nlrp3通路探讨三黄泻心汤对痰浊血淤型高脂血症内皮胞膜的调节作用，2017.01-2019.12，17万元，已结题，参加

17. 国家自然科学基金，81373697，小青龙汤通过PKCδ/ERK/PARP-1信号通路调节H1R表达治疗变应性鼻炎的机制研究，2014.01-2017.12，86万元，已结题，参加

承担的课程

中药药理学、药理学、医学免疫学

代表性研究论文(*为通讯作者，近五年)

1. Yun-liang Chen, Bo Xu, Zeng-feng Pan, Yan-ping Cai, Cai-yi Yang, Shui-ling Cao, Ke-han Chen, Xu-ting Xie, Meng Zhao, Peng-cheng Li, Xue-qian Xie, Xiao-yun Chen, Qing Wang, Lian Zhou*, Xia Luo*. Glycyrrhizic acid reduces neutrophil extracellular trap formation toameliorate colitis-associated colorectal cancer by inhibiting peptidylarginine deiminase 4. Journal of Ethnopharmacology, 2025, 2025 Feb 11:341:119337. doi: 10.1016/j.jep.2025.119337.

2. Caiyi Yang, Kehan Chen, Yunliang Chen, Xuting Xie, Pengcheng Li,Meng Zhao, Junjie Liang, Xueqian Xie, Xiaoyun Chen, Yanping Cai, BoXu, Qing Wang, Lian Zhou, Xia Luo*. Liquiritin improves macrophagedegradation of engulfed tumor cells by promoting the formation of phagolysosomes via NOX2/gp9lphox. Journal of pharmaceutical analysis, 2024, doi:https: //doiorg/10.1016/j.ipha.2024.101093.

3. Shaowei Huang, Xueqian Xie, Bo Xu, Zengfeng Pan, Junjie Liang, Meiling Zhang, Simin Pan, Xiaojing Wang, Meng Zhao, Qing Wang, Jinyan Chen, Yanyang Li, Lian Zhou*, Xia Luo*. Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells. Journal of Pharmaceutical Analysis, 2024,14(6): 100940. doi: 10.1016/j.jpha.2024.01.008.

4. Meiling Zhang, Yanping Chen, Qing Wang, Xiaoliang Lin, Ming Liang, Yingcheng Wang, Xiangliang Deng, Xia Luo*, Lian Zhou*. Lycium barbarum L. polysaccharide LBP3 exerts the anti-tumor effect through enhancing the function of tumor-associated dendritic cells via inhibiting IRE1α -XBP1 pathway of ER stress. Journal of Functional Foods, 2024, 112: 105950.

5. Xiaojing Wang, Xuting Xie, Yanyang Li, Xueqian Xie, Shaowei Huang, Simin Pan, Yanling Zou, Zengfeng Pan, Qing Wang, Jinyan Chen, Lian Zhou*, Xia Luo*. Quercetin ameliorates ulcerative colitis by activating arylhydrocarbon receptor to improve intestinal barrier integrity. Phytotherapy Research, 2023, 1–12.

6. Junjie Liang, Caiyi Yang, Pengcheng Li, Meiling Zhang, Xueqian Xie, Xuting Xie, Yunliang Chen, Qing Wang, Lian Zhou*, Xia Luo*. Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARγ signaling in mice. Phytomedicine, 2023, 121 (2023) 155116.

7. Meng Zhao, Xueqian Xie, Bo Xu, Yunliang Chen, Yanping Cai, Kehan Chen, Xinling Guan, Chen Ni, Xia Luo*, Lian Zhou*. Paeonol alleviates ulcerative colitis in mice by increasing short-chain fatty acids derived from Clostridium butyricum. Phytomedicine, 2023, 120 (2023) 155056.

8. Xiaojing Wang, Shaowei Huang, Meiling Zhang,Yulin Su, Zengfeng Pan, Junjie Liang, Xueqian Xie, Qing Wang, Jinyan Chen, Lian Zhou*, Xia Luo*. Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice. Journal of Ethnopharmacology, 2022, 302:115919.

9. Yulin Su, Junjie Liang, Meiling Zhang, Meng Zhao, Xueqian Xie, Xiaojing Wang, Zengfeng Pan, Shaowei Huang, Rong Yan, Qing Wang, Lian Zhou*, Xia Luo*. Wogonin regulates colonocyte metabolism via PPARγ to inhibit Enterobacteriaceae against dextran sulfate sodiuminduced colitis in mice. Phytotherapy Research, 2022, 37(3):872-884.

10. Shuang Luo, Jinrong He, Shaowei Huang, Xiaojing Wang, Yulin Su, Yanyang Li, Yanping Chen, Guanghua Yang, Bin Huang, Shaoju Guo, Lian Zhou*, Xia Luo*. Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe. Phytomedicine, 2022, 104:154106.

11. Shaowei Huang, Xiaojing Wang, Xueqian Xie, Yulin Su, Zengfeng Pan, Yanyang Li, Junjie Liang, Meiling Zhang, Simin Pan, Bo Xu, Linzhu Li, Jinyan Chen, Xia Luo*, Lian Zhou*. Dahuang Mudan decoction repairs intestinal barrier in chronic colitic mice by regulating the function of ILC3. Journal of Ethnopharmacology, 2022, 299:115652.

12. Zengfeng Pan, Xuting Xie, Yunliang Chen , Simin Pan, Zhiyun Wu, Caiyi Yang, Junjie Liang, Meilin Zhang, Qing Wang, Jinyan Chen, Lian Zhou*, Xia Luo*. Huang Qin Decoction inhibits the initiation of experimental colitis associated carcinogenesis by controlling the PAD4 dependent NETs. Phytomedicine, 2022, 107:154454.

13. Xueqian Xie, Meng Zhao, Shaowei Huang, Pengcheng Li, Peiqi Chen, Xia Luo, Qing Wang, Zengfeng Pan , Xiangling Li, Jinyan Chen, Bin Chen*, Lian Zhou*. Luteolin alleviates ulcerative colitis by restoring the balance of NCR-ILC3/NCR+ILC3 to repairing impaired intestinal barrier. International Immunopharmacology,2022, 112 (2022) :109251.

14. Yan-yang Li, Xiao-jing Wang, Yu-lin Su, Qing Wang, Shao-wei Huang, Zeng-feng Pan, Yan-ping Chen, Jun-jie Liang, Mei-ling Zhang, Xue-qian Xie, Zhi-yun Wu, Jin-yan Chen, Lian Zhou*, Xia Luo*. Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s, Acta Pharmacologica Sinica, 2021, 2021(0): 1-13.

15. Shaowei Huang, Yajun Fu, Bo Xu, Chang Liu, Qing Wang, Shuang Luo, Feifei Nong, Xiaojing Wang, Songyu Huang, Jinyan Chen, Lian Zhou*, Xia Luo*. Wogonoside alleviates colitis by improving intestinal epithelial barrier function via the MLCK/pMLC2 pathway. Phytomedicine. 2020; 68: 153179.

16. Shaowei Huang, Jinrong He, Yanping Chen, Xiaojing Wang, Yanyang Li, Yulin Su, Ruyan Wen, Xiuling Li, Guanghua Yang, Shuang Luo, Zhou*, Xia Luo*. Effect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway, Pharmaceutical Biology, 2022, 60(1): 108-118.

17. Xu Bo, Huang Shaowei, Chen Yanping, Wang Qing, Luo Shuang, Li Yanyang, Wang Xiaojing, Chen Jinyan, Luo Xia*, Zhou, Lian*. Synergistic effect of combined treatment with baicalin and emodin on DSS-induced colitis in mouse, Phytotherapy Research, 2021, 35(10): 5708-5719.

18. Ya-Jun Fu, Bo Xu, Shao-Wei Huang，Xia Luo, Xiang-Liang Deng, Shuang Luo, Chang Liu, Qing Wang, Jin-Yan Chen, Lian Zhou. Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14. Acta Pharmacol Sin, 2021, 42: 88-96.

19. Liu Chang#, Li Yanyang, Chen Yanping, Shaowei Huang, Xiaojing Wang, Shuang Luo, Yulin Su, Lian Zhou*, Xia Luo*. Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis. Mediators of Inflammation, 2020, 2020: 5918587.

20. Xia Luo, Xiaojing Wang, Shaowei Huang, Bo Xu, Shuang Luo, Yanyang Li, Qing Wang, Yanping Chen, Xiangliang Deng, Lingyun Liu, Lian Zhou. Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway. International immunopharmacology, 2021, 90.