刘芳,博士
职称/职位:副研究员,硕士/博士研究生导师
Chinese Chemical Letters 青年编委;Frontiers in Chemistry 客座副主编;广东省药学会生物医药分析专委会委员;广东省精准医学应用学会分子影像分会委员;Analytical Chemistry,Chemical Communications等SCI期刊审稿人。
Email:fangliu@gzucm.edu.cn
Group Page:https://www.x-mol.com/groups/fangliu
教育及工作经历:
2017.12 / 至今 广州中医药大学,杏林青年学者
2017.07 / 2017.11 广州医科大学,药学院,副研究员
2015.07 / 2017.06 博士后,斯坦福大学化学系,合作导师:Yan Xia & Dimitre Hristov
2014.08 / 2015.05 博士后,乌尔姆大学有机化学所(德国),合作导师:Tanja Weil
2010.01 / 2014.07 博士,新加坡南洋理工大学化学与生物化学系,导师:Bengang Xing
2007.09 / 2009.12 硕士,兰州大学,广州生物医药与健康研究院 (GIBH),联合培养
2003.09 / 2007.07 学士,兰州大学,生命科学国家理科基地班
研究方向:生物分析化学,化学生物学
1. 分子发光体系的设计,及其在药物/生化分析中的应用。
2. 生物正交化学及探针构建,药物化学生物学研究。
科研及教学课题:
研究工作获国家自然科学基金、广东省教育厅重点领域专项、广州中医药大学青年拔尖团队培育,以及市厅级产学研项目等科技项目支持。
承担课程:主要承担《药物发现关键技术》、《药物化学》等本科生课程,《药学专论》等研究生课程。
代表性研究论文:
1. H. Ma#, Q. Wang#, L. Huang, Y. Wang, F. Chen, F. Liu*, Y. Ma*. Block Electrochemiluminescence of Luminol through O-etherification and its Application in Sensing of β-glucosidase. Anal. Chem. 2025, 97, 594-601.
2. X. Zou, Y. Lin, S. Zhang, T. Deng, X. Xu, Y. Zhou*, Z. Liu, W. Lu, Q. Hu, C. Lin, C. Zhu*, F. Liu*. Fluorescence detecting glycopeptide antibiotics via a dynamic molecular switch. Anal. Chim. Acta, 2024, 1294, 342309.
3. C. Guo, Y. Wu, Q. Wang, X. Li, T. Deng, X. Xia, L. Li*, H. Li, C. Lin, C. Zhu*,
F. Liu*. Super-resolution Imaging Lysosome Vesicles and Establishing a Gallbladder-Visualizable Zebrafish Model via a Fluorescence Probe. Talanta, 2024, 279, 126656.
4. Z. Zhou, F. Chen, X. Xia, D. Ye, R. Zhou*, L. Li, T. Deng, Z. Ding*, F. Liu*. Developing a Fluorescence Substrate for HRP-based Diagnostic Assays with Superiorities over the Commercial ADHP,Chin. Chem. Lett. 2024, 35, 108970.
5. F. Chen#, X. Xia#, D. Ye, T. Li, X. Huang, C. Cai, C. Zhu, C. Lin, T. Deng*, F. Liu*. A Green-Emitting Luminol Analogue as the Next Generation Chemiluminescent Substrate in Biochemical Analysis. Anal. Chem. 2023, 95, 5773-5779. 封面论文
6. F. Chen, Y. Zhang, T. Li, D. Peng, Z. Qi, J. Song, T. Deng*, F. Liu*. Discovering Ester and Ether Derivatives of Luminol as Advanced Chemiluminescence Probes. Chin. Chem. Lett. 2023, 34, 107496.
7. Y. Wu, W. Huang, D. Peng, X. Huang, J. Gu, S. Wu, T. Deng*, F. Liu*. Synthesis of dihydroquinolines as scaffolds for fluorescence sensing of hydroxyl radical. Org. Lett. 2021, 23, 135-139,封面论文
8. T. Deng#, Z. Qi#, Y. Wu, J. Zhao, L. Wang, D. Peng, Y. Zhang, X. Huang, F. Liu*. A Photosensitizing Perylenediimide Dye Lights up Cell Nucleolus through Visible Light-mediated Intracellular Translocation. Dyes Pigm. 2021, 196, 109722.
9. L. Zhao#, F. Chen#, W. Huang, H. Bao, Y. Hu, X. Huang, T. Deng*, F. Liu*. A fluorescence turn-on assay for simple and sensitive determination of hemin and blood stains. Sens. Actuators, B. 2020, 304, 127392.
10. T. Deng#, X. Wang#, S. Wu, S. Hu, W. Liu, T. Chen, Z. Yu, Q. Xu* and F. Liu*. A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish. Chem. Commun., 2020, 56, 4432-4435.
11. T. Deng, S. Hu, X. Huang, J. Song, Q. Xu, Y.Wang, F. Liu* A novel strategy for colorimetric detection of hydroxyl radicals based on a modified Griess test. Talanta, 2019, 195, 152-157.
12. J. Mu, F. Liu*, M. S. Rajab, M. Shi, S. Li, C. Goh, L. Lu, Q. Xu, B. Liu, L. G. Ng, B. Xing*, Small molecule FRET Reporter for real-time visualization of cell-surface proteolytic enzyme functions. Angew. Chem. Int. Ed, 2014, 53, 14357-14362.
授权专利:
获授权发明专利10余项,转让专利3项,到账金额100万。