zhangxj@gzucm.edu.cn

博士，教授，博士生导师，中共党员，药理教研室副主任。2014年入选广东省高等学校“千百十人才培养工程”第八批省培养对象，2018年入选国家中医药管理局第一批中医药外向型优秀骨干人才。长期从事中医药抗炎免疫药理研究，现担任广东省免疫学会第六届常务理事、中国免疫学会中医药免疫分会理事。

教育经历：

2008-04 至 2012-06, 香港浸会大学，访问学者、博士后，导师卞兆祥教授

2005-04 至 2008-03, 香港浸会大学, 药理学, 博士

2000-09 至 2003-06, 广州中医药大学, 中药现代化, 硕士

1993-09 至 1997-06, 广州中医药大学, 中药学, 学士

工作经历：

2019-12 至 今, 广州中医药大学, 中药学院, 教授

2014-01 至 2019-12, 广州中医药大学, 中药学院, 副教授

2018-08 至 2019-08, The University of Texas Medical Branch, the Department of Microbiology & Immunology，国家公派访问学者

2014-09 至 2015-07, 南方医科大学, 风湿免疫科，教育部高等学校青年骨干教师国内访问学者，导师孙尔维教授

2012-06 至 2013-12, 广州中医药大学, 中药学院, 讲师

2003-06 至 2004-05, 广州医药集团有限公司, 广州汉方现代中药研究开发有限公司

1997-06至2000-08 中山市中医院，药剂科

研究方向

中医药抗炎免疫药理、中药抗肿瘤药理。

科研课题

1.基于巨噬细胞调节肠隐窝LGR5+干细胞增殖探讨薯蓣皂苷促溃疡性结肠炎黏膜修复的作用及机制，广东省自然科学基金，2024A1515011931, 15万元，2024/1-2027/12，主持，在研。

2.益气除痰方干预COX-2-PGE2/β2 Integrin信号抑制肿瘤相关中性粒 细胞促癌极化和黏附的抗肺癌转移机制，国家自然科学基金面上项目，82374534，49万元，2024/1-2027/12（排名第2），在研。

3.基于AMPK/MFN2/MCU/Ca2+信号探讨薯蓣皂苷调节巨噬细胞线粒体代谢和治疗UC的机制，广州市科技计划，202201011634，5万元，2021/3-2025/9,主持,在研。

4.基于AMPK调节mTORC1/mTORC2信号探讨薯蓣皂苷影响巨噬细胞极化和治疗UC的机制，国家自然科学基金面上项目, 82074102，55万元，2021/1-2024/12, 主持,在研。

5.基于糖代谢调节巨噬细胞线粒体自噬探讨黄藤素治疗溃疡性结肠炎的作用机制,广州中医药大学薪火计划优秀项目资助，2020/1-2022/1, 主持, 结题。

6.基于线粒体自噬调控NLRP3炎症小体活化探讨巴马亭治疗溃疡性结肠炎的作用机制，广东省自然科学基金，2018/4-2020/4，10万元，结题。

7.基于代谢组学的广藿香治疗炎症性肠病的机制研究 (A2013232),广东省自然基金2018/1-2020/12，10万元，主持, 结题。

8.小儿七星茶对肠道菌群的调整作用，广州王老吉药业股份有限公司，2016/9-2017/1, 5万元，主持，结题。

9.基于色氨酸代谢通路调节Th/Treg免疫功能探究广藿香活性成分抗IBD作用机制,广东省高层次人才项目，2016/4-2018/3, 30万元, 主持, 结题。

10.基于靶向代谢组学探究广藿香活性成分治疗炎症性肠病的作用和机理，国家自然科学基金面上项目，青年项目，2014/1-2016/12, 20万元, 主持, 结题。

11.小儿七星茶通便作用及机理研究，广州王老吉药业股份有限公司，2014/9-2015/8, 20万元，主持, 结题。

12.基于靶向代谢分析研究广藿香治疗炎症性肠病的作用机理，广东省自然科学基金，自由申请项目,2013/10—2015/10，3万元, 主持, 结题。

发表论文

1.Huang BY,Lu SR, Chen LX,Bai LL, Li CC, Xu CQ, Li MJ, Zeng JX, Zhang EX*, Zhang XJ*. Shikonin ameliorated LPS-induced acute lung injury in mice via modulating MCU-mediated mitochondrial Ca2+ and macrophage polarization. Phytomedicine, 2024, 135:156043

2.Lin YK, Hong YL, Liu CY, Lin WQ, Liang K, Deng SQ, Zhang XJ* Zeng JX*, Wang S*. Jiawei Bai-Hu-Decoction ameliorated heat stroke-induced brain injury by inhibiting TLR4/NF-κB signal and mitophagy of glial cell, Journal of Ethnopharmacology, 2024. 2024 Nov 15:334:118571

3.Zeng JX, Xu CQ, Chen LX, Li MJ, Yang JY, Nie LX, Zhang MQ*, Zhang XJ*, Zhang EX*. Anti-glioma effect of Buthus martensii Karsch (BmK) scorpion by inhibiting myeloid-derived suppressor cells and activating T cells in tumor microenvironment, Journal of Functional Foods, 2024. 2024.106163.

4.Chen LX, Li MJ, Xu CQ, Zeng JX, Yang JY, Nie LX, Wang MQ*, Zhang EX*, Zhang XJ*. (Co-corresponding Author). Yi Qi Chu Tan Formula (YQCTF) inhibited the progress of lung cancer via regulating tumor-associated neutrophil: An integrated study of network pharmacology, proteomics and pharmacodynamics. Journal of Ethnopharmacology. 2024; 318(Pt B):116943.

5.Li CC, Lu SR, Xu CQ, Huang BY, Wang QM, Zhang EX*, Zhang XJ* (Co-corresponding Author) . Shikonin mediated anti-acute lung injury and hemostatic effects via inhibiting uPA. Journal of Functional Foods, 2023,105,405527. ISSN: 1756-4646

6.Huang BY†, Wang QM†, Jiang L†, Lu SR, Li CC, Xu CQ, Wang CY*, Zhang EX*, Zhang XJ* (Co-corresponding Author). Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages, Front Pharmacol.2022.13:926945.

7.Wu MM, Wang QM, Huang BY, Mai CT, Wang CL, Wang TT, Zhang XJ* (Corresponding Author). Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization. Pharmacological Research, 2021;172:105796. ISSN: 1043-6618.

8.Wu MM, WangCL, Mai CT, Chen JN, Lai XP, He L*, Zhang XJ*(Co-corresponding Author). Flavonoids from Livistona chinensis fruit ameliorates LPS/D-GalN-induced acute liver injury by inhibiting oxidative stress and inflammation. Journal of Functional Foods 61. 2019, 103460.

9. Mai CT, Wu MM, Wang CL, Su ZR, Cheng YY*, Zhang XJ* (Co-corresponding Author). Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation. Molecular Immunology. Mol Immunol. 2019 Jan;105:76-85.

10.Zhang XJ, Yuan ZW , Qu C, Yu XT, Huang T, Chen P, Su ZR, Dou YX, Wu JZ, Zeng HF, Xie Y, Chen JN, Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota,  Pharmacol Res. 2018;137:34-46.

11.Liu X, Yu X, Xu X, Zhang X*, Zhang XJ*.  The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism. Food Funct. 2018. 9(11):5936-5949.

12.Yu XT, Xu YF, Huang YF, Qu C, Xu LQ, Su ZR, Zeng HF, Zheng L, Yi TG, Li HL, Chen JP*, Zhang XJ*. Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. PLoS One. 2018 Mar 14;13(3):e0194069.

13. Su JY, Li CL, Yu XT, Yang GH, Deng JH, Su ZR, Zeng HF, Chen JN, Zhang XJ*, Lai XP*. Protective Effect of Pogostone on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis via Inhibition of T Helper Cell, Front Pharmacol, 2017.11, .17, 8(892): 1~10

14.Qu C, Yuan ZW, Yu XT, Huang YF, Yang GH, Chen JN, Lai XP, Su ZR, Zeng HF, Xie Y*, Zhang XJ* (Co-corresponding Author). Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism. Pharmacol Res. 2017;121:70-82.

15.Qu C, Yang GH, Zheng RB, Yu XT, Peng SZ, Xie JH, Chen JN, Wang XF, Su ZR*, Zhang XJ* (Co-corresponding Author). The immune-regulating effect of Xiao'er Qixingcha in constipated mice induced by high-heat and high-protein diet, BMC Complement Altern Med. 2017 Mar 31;17(1):185.

16.Yu XT, Yang GH, Jiang H, Lin SH, Liu YH, Zhang X, Zeng HF, Su ZR, Huang S, Shen LL*, Zhang XJ *(Co-corresponding Author), Patchouli oil ameliorate rat acute colitis: a targeted metabolite analysis of TNBS rats, Experimental and Therapeutic Medicine.

17.Zhao XN, Liang JL, Chen HB, Liang YE, Guo HZ, Su ZR, Li YC*, Zhang XJ* (Co-corresponding Author), Anti-Fatigue and Antioxidant Activity of the Polysaccharides Isolated from Millettiae speciosae Champ. Leguminosae, Nutrients. 2015, 21;7(10):8657-69.

18.Zhao XN, Wang XF, Liao JB, Guo HZ, Yu XD, Liang JL, Zhang X, Su ZR*, Zhang XJ* (Co-corresponding Author), Zeng HF,* Antifatigue Effect of Millettia Speciosae Champ (Leguminosae) Extract in Mice, Trop J Pharm Res 2015; 14 (3): 1319-1326

19.Wang XF, Huang XD, Zhao XN, Xie JH, Su JY, Mo ZZ, Chen JN, Su ZR, Zhang XJ* (Co-corresponding Author) and Chen WP*, Prokinetic and laxative effects of xiao'er qixingcha, a household pediatric herbal formula,  Afr J Tradit Complement Altern Med, 2015, 12, (5), 89-98.

20.Su ZQ, Liao JB, Liu YH, Liang YZ, Chen HM, Chen XY, Lai XP, Feng XX, Wu DW, Zheng YF*, ZhangXJ*(Co-corresponding Author) and Li YC, Protective actions of patchouli alcohol isolated from Pogostemon cablinon lipopolysaccharide-induced acute lung injury in mice, Experimental and Therapeutic Medicine, 2015,26(2):328-337

21.Kong SZ, Shi XG, Feng XX, Li WJ, Liu WH, Chen ZW, Xie JH, Lai XP, Zhang SX*, Zhang XJ* (Co-corresponding Author), Su ZR. Inhibitory Effect of Hydroxysafflor Yellow A on Mice Skin Photoaging Induced by UV Irradiation, Rejuvenation Research. 2013,16(5):404-13

22.Wu XL, Li CW, Chen HM, Su ZQ, Zhao XN, Chen JN, Lai XP*, Zhang XJ* (Co-corresponding Author), Su ZR. Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds of Chrysanthemum indicum Linnén. Evidence-Based Complementary and Alternative Medicine. 2013.

23.Zhang XJ, Choi FK, Zhou Y, Leung FP, Tan Shun, Lin SH, Xu HX, Jia W, Sung JY, Cai ZW, Bian ZX, Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics: A pilot study, FEBS Journal, 2012, 279(13):2322-2338.

24.Zhang XJ, Leung FP, Hsiao WL, Tan S, Li S, Xu HX, Sung JY, Bian ZX. Proteome profiling of spinal cord and DRG in rats with TNBS-induced colitis. World Journal of Gastroenterology. 2012, 18(23):2914-28.

25.Chen HL, Zhang XJ, Qi SD, Xu HX, Sung JJ, Bian ZX. Simultaneous determination of glutamate and aspartate in rat periaqueductal gray matter microdialysates by capillary electrophoresis with laser-induced fluorescence, Journal of Chromatography B-Analytical Technologies in the Biomedical And Life Sciences, 2009;877:3248-52.

26.Zhang XJ, Chen HL, Li Z, Zhang HQ, Xu HX, Sung JJ, Bian ZX. Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A1 receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway, Pharmacology, Biochemistry and Behavior, 2009,94:88-97.

27.Li Z, Zhang XJ, Xu HX, Sung JJ, Bian ZX. Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats, European Journal of Pharmacology, 2009, 606:199-204.

28.Zhang XJ, Li Z, Chung EK, Zhang HQ, Xu HX, Sung JJ, Bian ZX. Activation of extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats. Journal of Molecular Neuroscience. 2009, 37:274-87.

29.Zhang XJ, Li Z, Leung WM, Liu L, Xu HX, Bian ZX. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats, Journal of Pain. 2008, 9: 497-505.

30.Chung EK, Zhang XJ, Li Z, Zhang H, Xu H, Bian Z., Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat. Brain Research. 2007, 1153: 68-77.

31.Chung EK, Zhang XJ, Xu HX, Sung JJ, Bian ZX. Visceral hyperalgesia induced by neonatal maternal separation is associated with nerve growth factor-mediated central neuronal plasticity in rat spinal cord. Neuroscience. 2007,149:685-95.

获奖情况

2021年获广东省科技进步奖二等奖(牛大力等四种保健植物林下培育利用关键技术，排名第10)。

2023年获第三届智慧树林课程思政示范案例教学大赛，普通本科教育赛道获得二等奖。

人才培养

2023年指导2名本科生获得第七届全国医药院校药学、中药学专业大学生实验技能展示活动一等奖、二等奖。

已培养毕业博士生3名，硕士研究生10名，其中1人获得省优秀毕业生，5人获得校级优秀毕业生，4人获得国家奖学金，现在读博士研究生1名，硕士研究生7人。

参与出版教材

1.《药理学实验》全国普通中医药院校药学类专业“十三五”规划教材，中国医药科技出版社，北京，2018.8

2．《药理学》全国普通中医药院校药学类专业“十三五”规划教材，中国医药科技出版社，2018.8

3．《药理学》，中国医药科技出版社，北京，2014.8

4.《药理学实验》，中国医药科技出版社，北京，2015.1

5.《药理学》，中国中医药出版社，北京，2016.08

6.《药理学》，人民卫生出版社，北京，2016.06