姓名：马东明

研究员、中药学博士生导师

简介：博士，主要从事中药资源与植物次生代谢研究，近年来以第一作者或通讯作者在国际学术期刊Cell Reports,Plant Biotechnology Journal,Plant Journal, Plant Physiology, Industrial Crops and Products等发表多篇论文，其中一篇文章在Plant Physiology同期受到国外学者点评。主持或参与国家级、省部级及企业横向项目多项。指导多名学生获得国家级奖学金、校级优秀毕业论文、优秀毕业及大学生创新创业项目。 Email：madm@gzucm.edu.cn

教育与工作经历

[1]2016/7-至今    广州中医药大学  中药学院     研究员

[2]2011/9-2016/6 美国北卡罗莱那州立大学   博士后

[3]2011/2-2011/8  香港中文大学 研究助理

[4]2005/07-2009/06中国科学院植物研究所  植物光合作用与环境生理重点实验室 博士

[5]2002/09-2005/07中国农业大学 农学与生物技术学院硕士

[6]1998/09-2002/07 东北农业大学 农学 学士

研究方向与领域：

1）药用植物资源保护开发与综合利用；

2）重要药用活性成分的生物合成途径解析；

3）多酶级联反应与代谢工程获取高附加值的天然代谢产物；

研究课题

[1]广州市科技局, 广州市重点研发子课题, 2025B03J0144, 基于AI技术预测、改造和验证野菊花合成地奥司明关键酶蛋白的结构和功能, 2025-11 至 2028-11,  在研, 主持

[2]中药合成生物学研究湖南省重点实验室（湖南省科学技术厅）, 中药合成生物学研究湖南省重点实验室开放课题, HCSW2024-02, 转录因子调控野菊蒙花苷生物合成的分子机制研究, 2024-12 至 2026-12, 在研, 主持

[3]广东省科学技术厅, 广东省自然科学基金面上项目, 2024A1515010381, 野菊花中抗静脉曲张药用活性成分地奥司明的生物合成途径研究, 2024-01 至 2026-12, 15万元, 在研, 主持

代表性论文论著

[1]Li Li; Zhiteng Luo; Zhaoyin He; Jie Tang; Wuke Wei; Ruoting Zhan*; Huihao Zhou*; Dongming Ma*; The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid, Plant Biotechnology Journal, 2026

[2]Zhang Q, Wu Q, Shi W, Deng Y, Zhan R*, Ma D* (2025) Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum. Plant Biotechnology Journal. doi:10.1111/pbi.70426

[3]Yinai Deng; Peng Yang; Qianle Zhang; Qingwen Wu; Lingfang Feng; Wenjing Shi; Qian Peng;Li Ding; Xukai Tan; Ruoting Zhan*; Dongming Ma*; Genomic insights into the evolution of flavonoid biosynthesis and O-methyltransferase and glucosyltransferase in Chrysanthemum indicum, Cell Reports, 2024, 43(2)

[4]Qingwen Wu; Min Wei; Lingfang Feng; Li Ding; Wuke Wei; Jinfen Yang; Xiaojing Lin; Huilin Liang; Ruoting Zhan*; Dongming Ma*; Rhamnosyltransferases Involved in the Biosynthesis of Flavone Rutinosides in Chrysanthemum Species, Plant Physiology, 2022, 190(4): 2122-2136

[5]Yang P, Chen Y, Wang T, Huang X, Zhan R*, Yang J*, Ma D* (2024) Nudix hydrolase WvNUDX24 is involved in borneol biosynthesis in Wurfbainia villosa. Plant Journal 118 (4):1218-1231. doi:10.1111/tpj.16669

[6]Ding L, Huang J, Tang J, Wu Q, Yang P, Zhan R*, Ma D* (2025) Collinearity analysis and characterization of rhamnosyltransferases from Chrysanthemum morifolium, Mikania micrantha and Stevia rebaudiana. Planta 262 (2):24. doi:10.1007/s00425-025-04742-w

[7]Hui Liu; Shuangcheng Liang; Meixian Zhu; Wenjing Shi; Chong Xu; Wuke Wei; Ruoting Zhan*;Dongming Ma*; A fused hybrid enzyme of 8-hydroxygeraniol oxidoreductase (8HGO) from Gardenia jasminoides and iridoid synthase (ISY) from Catharanthus roseus significantly enhances nepetalactol and iridoid production, Planta, 2024, 259(3)

[8]Feng L, Lin Y, Cai Y, Wei W, Yang J, Zhan R*, Ma D* (2023) Terpenoid VOC profiles and functional characterization of terpene synthases in diploid and tetraploid cytotypes of Chrysanthemum indicum L. Plant Physiol Biochem 200:107766. doi:10.1016/j.plaphy.2023.107766

[9]Lin X, Huang L, Liang H, Hou C, Ling X, Chen Y, Yang P, Wu Q, Zhao H, Wu S, Zhan R, Ma D*, Yang J* (2023) Genome-wide identification and functional characterization of borneol dehydrogenases in Wurfbainia villosa. Planta 258 (4):69. doi:10.1007/s00425-023-04221-0

[10]Deng Y, Li L, Peng Q, Feng L, Yang J, Zhan R*, Ma D* (2022) Isolation and characterization of AaZFP1, a C2H2 zinc finger protein that regulates the AaIPPI1 gene involved in artemisinin biosynthesis in Artemisia annua. Planta 255 (6):122. doi:10.1007/s00425-022-03892-5

[11]Chong Xu; Peng Ye; Qingwen Wu; Shuangcheng Liang; Wuke Wei; Jinfen Yang; Weiwen Chen;Ruoting Zhan; Dongming Ma*; Identifcation andfunctional characterization ofthree iridoid synthases inGardenia jasminoides, Planta, 2022, 255(58)

[12]Zhou Z, Xian J, Wei W, Xu C, Yang J, Zhan R, Ma D* (2021) Volatile metabolic profiling and functional characterization of four terpene synthases reveal terpenoid diversity in different tissues of Chrysanthemum indicum L. Phytochemistry 185:112687

[13]Ye P, Liang S, Wang X, Duan L, Jiang-Yan F, Yang J, Zhan R*, Ma D* (2019) Transcriptome analysis and targeted metabolic profiling for pathway elucidation and identification of a geraniol synthase involved in iridoid biosynthesis from Gardenia jasminoides. Industrial Crops and Products 132:48-58.

[14]Jiang Y, Ji X, Duan L, Ye P, Yang J, Zhan R, Chen W*, Ma D* (2019) Gene mining and identification of a flavone synthase II involved in flavones biosynthesis by transcriptomic analysis and targeted flavonoid profiling in Chrysanthemum indicum L. Industrial Crops and Products 134:244-256.

其他代表性业绩

[1]马东明; 张千乐; 邓银爱; 詹若挺; 植物多基因串联载体的构建及应用于植物底盘中生产黄酮芸香糖苷类化合物, 2025-07-02, 中国, 202510906938.8 (专利)