国际中医药转化医学研究所
王彩艳
发布时间:2019-06-06      来源:       点击:

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职称:研究员  学位:博士

学院: 中药学院(国际中医药转化医学研究所)

E-mail:  wangcaiyan@gzucm.edu.cn

办公电话:020-39358875

办公室:广州大学城广州中医药大学针灸楼2楼

个人获得荣誉:国家优青获得者、广东省青年珠江学者

                                                                                 广州中医药大学“杏林青年学者”

教育工作经历

2015年博士毕业于中山大学,随后在中山大学有害生物控制与资源利用国家重点实验室从事博士后研究。2019年美国加州大学洛杉矶分校分子成像中心访问学者。2017年以杏林青年学者身份引进到广州中医药大学工作至今。

研究方向

研究领域:中药抗炎结构药理学

研究方向:(1)中药药效分子作用靶点发现与确证;

                            (2)基于“成分-靶点”互作结构的抗炎机制解析。

科研及教学课题

1. 国家自然科学基金优秀青年科学基金项目,823220742024/01-2026/12200万元,主持,在研。

2. 广州中医药大学青年拔尖人才 (团队) 培育揭榜挂帅项目,2023/09-2026/0950万元,主持,在研。

3. 国家自然科学基金面上项目,822742142023/01-2026/1252万元,主持,在研。

4. 广东省教育厅重点领域项目,2022ZDZX20102023/01-2025/1210万元,主持,在研。

5. 广州市基础与应用基础研究项目,2022010114202022/04-2024/035万元,主持,在研。

6. 广东省教育厅,2019年广东省高等学校青年珠江学者,2019/10-2022/09, 100万,主持,结题。

7. 国家自然科学基金青年项目,317006252018/01-2020/1224万元,主持,结题。

8. 广东省基础与应用基础面上项目,2017A0303101902017/05-2020/510万元,主持,结题。

9. 中国博士后科学基金特别资助,2017T1006542017/01-2017/0615万元,主持,结题。

承担的课程

        本科生教学:《药理学》《药物毒理学》和《结构生物学与现代药学研究》;

        研究生教学:《药学专论》的蛋白质结构药理学部分。


代表性论文

1. Caiyan Wang#(王彩艳,第一作者), Xiaojun Teng, Chuang Wang, Binjie Liu, Runze Zhou, Xueyu Xu, Huawei Qiu, Yu Fu, Rongjin Sun, Zuhui Liang, Rong Zhang, Zhongqiu Liu*, Lin Zhang*, Lijun Zhu*. Insight into the mechanism of Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea based on regulating the gut microbiota and inhibiting Gut β-GUS. Phytomedicine, 2023, 120:155040.

2. Huan Lan, Ying Zhang, Minqi Fan, Bingxin Wu, Caiyan Wang*(王彩艳,通讯作者). Pregnane X receptor as a therapeutic target for cholestatic liver injury. Drug metabolism reviews. 2023, 1-17.

3. Fang Wu, Yuanyuan Cheng, Jianfu Zhou, Xuehua Liu, Rongwu Lin, Songtao Xiang, Zhongqiu Liu*, Caiyan Wang*(王彩艳,通讯作者).  Zn2+ regulates human oxalate metabolism by manipulating oxalate decarboxylase to treat calcium oxalate stones. Int J Biol Macromol. 2023, 15;234:123320.

4. Zibo Li#, Lin Jiang#, Jiadong Ni, Yuanhang Xu, Fang Liu, Wenming Liu, Shaogui Wang*, Zhongqiu Liu*, Caiyan Wang*(王彩艳,通讯作者). Salvianolic acid B Suppresses Hepatic Fibrosis by Targeting Ceramide Glucosyltransferase in Hepatic Stellate Cells. Acta Pharmacologica Sinica, 2023, 44(6):1191-1205.

5. Lin Zhang, Yuanhang Xu, Xuerong Zhang, Yibing Yang, Jiangyong Gu, Zhongqiu Liu*, Caiyan Wang*(王彩艳,通讯作者). The Structural Basis of Conserved Residue Variant Effect on Enzyme Activity of UGT2B15, BBA - Proteins and Proteomic, 2023, 1871(3):140888.

6. Tian-Tian Wang#, Li-Chun Zhang#, Zhen Qin, Shu-Jun Chen , Jing-Min Zeng, Jing-Yan Li, Lin An, Cai-Yan Wang(王彩艳), Yong Gao, LiMing Wang, ZhongXiang Zhao*, ZhongQiu Liu*, Shao-Gui Wang*. Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation. Acta Pharmacol Sin. 2023, doi: 10.1038/s41401-023-01139-x.

7. Tao Su, Suchao Huang, Yanmin Zhang, Yajuan Guo, Shuwei Zhang, Jiaji Guan, Mingjing Meng, Linxin Liu, Caiyan Wang(王彩艳), Dihua Yu, Hiu-Yee Kwan, Zhiying Huang, Qiuju Huang, Elaine Lai-Han Leung, Ming Hu, Ying Wang, Zhongqiu Liu*, Linlin Lu*. miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis. Acta Pharm Sin B. 2022 ;12(2):821-837.

8. Juan Liu, Yuxin Zhuang, Jianlin Wu, Qiang Wu, Meixian Liu, Yue Zhao, Zhongqiu Liu, Caiyan Wang(王彩艳), Linlin Lu, Yingjiao Meng, Kawai Lei, Xiaojuan Li, Qibiao Wu, Elaine Lai-Han Leung, Zhengyang Guo, Liang Liu*, Ting Li*. IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα. Acta Pharm Sin B.  2022, 12(2):651-664.

9. Baoyuan Huang, Qiumei Wang, Lin Jiang, Shuru Lu, Chengcheng Li, Chunqi Xu, Caiyan Wang*(王彩艳,共同通讯作者), Enxin Zhang*, Xiaojun Zhang*. Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages. Frontiers in Pharmacology, 2022, 17;13:926945.

10. Xuerong Zhang, Shehan Li, Zibo Li, Liangkai Cheng, Zhongqiu Liu, Caiyan Wang*(王彩艳,通讯作者). The therapeutic potential of targeting Hsp90-Cdc37 interactions in several diseases. Current Drug Targets, 2022. 23(10):1023-1038.

11. Lin Zhang, Wei Xie, Xiaojun Teng, Kui Wang, Wei Xie*, Caiyan Wang*(王彩艳,通讯作者). Improving the Extraction of Active Ingredients from Medicinal Plants by XynA Modification. Journal of Chemistry, 2022, doi:10.1155/2022/2483797.

12. Xuerong Zhang#, Shehan Li#, Zibo Li, Liangkai Cheng, Zhongqiu Liu*, Caiyan Wang*(王彩艳,通讯作者). The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases. Current Drug Targets, 2022, 23(10):1023-1038.

13. Zibo Li, Lin Zhang, Dan Liu, Caiyan Wang*(王彩艳,通讯作者). Ceramide glycosylation and related enzymes in cancer signaling and therapy. Biomedicine & Pharmacotherapy, 2021, 139:111565.

14. Yuanyuan Cheng#, Liangkai Cheng#, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang*(王彩艳,共同通讯作者), Zhongqiu Liu*. Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. Theranostics, 2021; 11(2): 861-877.

15. Dan LiuQi YuZibo LiLin ZhangMing HuCaiyan Wang*(王彩艳,共同通讯作者)Zhongqiu Liu*, UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder, Biochemical Pharmacology, 2021, 190:114592.

16. Liangkai Cheng, Huihui Wang, Shehan Li, Zhongqiu Liu, Caiyan Wang*(王彩艳,通讯作者). New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations, Life Sciences, 2021, 282:119791.

17. Wei Xie, Qi Yu, Ruiqing Zhang, Yun Liu, Ruoting Cao, Sidi Wang, Ruoting Zhan, Zhongqiu Liu, Kui Wang*, Caiyan Wang*(王彩艳,通讯作者). Insights into the Catalytic Mechanism of a Novel XynA and Structure-Based Engineering for Improving Bifunctional Activities. Biochemistry2021, 60(26):2071-2083.

18. Ying Zhang, Caiyan Wang*(王彩艳,通讯作者). Demethyltransferase AlkBH1 Substrate Diversity and Relationship to Human Diseases. Molecular Biology Reports, 2021, 48(5):4747-4756.

19. Wei Liu#, Yanxiang Cui#, Caiyan Wang (王彩艳), Zihang Li, Danyang Gong, Xinghong Dai, Guo-Qiang Bi, Ren Sun, Z Hong Zhou*. Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus. Nature Microbiology, 2020, 5(10):1285-1298.

20. Liangkai Cheng, Hong Zhang, Fang Wu, Zhongqiu Liu, Yuanyuan Cheng*, Caiyan Wang*(王彩艳,通讯作者). Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease. Oxidative Medicine and Cellular Longevity. 2020, 4683943.

21. Lin Zhang#, Lijun Zhu#, Wei Qu, Fang Wu, Ming Hu, Wei Xei*, Zhongqiu Liu*, Caiyan Wang*(王彩艳,通讯作者). Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochemical Pharmacology, 2020, 172:113753.

22. Hong Li, Ying Zhang, Yajuan Guo, Rong Liu, Qi Yu, Lingzhi Gong, Zhongqiu Liu*, Wei Xie*, Caiyan Wang*(王彩艳,通讯作者). ALKBH1 Promotes Lung Cancer by Regulating m6A RNA Demethylation. Biochemical Pharmacology, 2020, 114284.

23. Qi Yu, Zonglang Liao, Dan Liu, Wei Xie, Zhongqiu Liu, Guochao Liao*, Caiyan Wang*(王彩艳,通讯作者). Small molecule inhibitors of the prostate cancer target KMT2D. Biochemical and Biophysical Research Communications, 2020, 10;533(3):540-547.

24. Dan Liu, Lin Zhang, Lixin Duan, Jinjun Wu, Ming Hu, Zhongqiu Liu*, Caiyan Wang*(王彩艳,通讯作者). Potential of Herb-Drug/Herb Interactions between Substrates and Inhibitors of UGTs Derived from Herbal Medicines. Pharmacological Research, 2019, 150:104510.

25. Fang Wu, Liangkai Cheng, Qi Yu, Lin Zhang, Hong Li, Caiyan Wang*(王彩艳,通讯作者). Purification and functional characterization of the C-terminal domain of the β-actin-binding protein AIM1 in vitro, Molecules. 2018, 23(12): 3281.

26. Caiyan Wang#(王彩艳,第一作者), Qian Jia#, Jianhua Zeng, Ran Chen, Wei Xie*. Structural insight into the methyltransfer mechanism of the bifunctional Trm5. Science Advances, 2017, 3(12):1-9.

27. Caiyan Wang(王彩艳,第一作者), Jianhua Zeng, Wei Xie*, A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1. FEBS Letters, 2017, 591(2):433-441.

28. Caiyan Wang#(王彩艳,第一作者), Qian Jia #, Ran Chen, Yuming Wei, Juntao Li, Jie Ma, Wei Xie*. Crystal structures of the bifunctional tRNA methyltransferase Trm5a. Scientific Reports, 2016, 6: 33553.

29. Caiyan Wang(王彩艳,第一作者), Yu Guo, Qingnan Tian, Qian Jia, Yuanzhu Gao, Qinfen Zhang, Chun Zhou, Wei Xie*. SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Research, 2015, 43(21): 10534-10545.




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